RARE NTM COMPLICATING UNDERLYING SEVERE PERSISTENT ASTHMA

TOPIC: Chest Infections TYPE: Fellow Case Reports INTRODUCTION: Nontuberculous mycobacterium (NTM) associated pulmonary infections are a rising cause for concerns globally. There has been surge of NTM reported cases in the United States over past decade. The most common from isolated due to Mycobacterium avium complex (MAC), kansasii, and abscessus. fortuitum group species subset rapid growing mycobacteria (RGM) that encountered as emerging opportunistic pathogens. compromises M. fortuitum, peregrinum, senegalense, alvei, houstonense, neworleansense, boenickei, septicum, porcinum. This subgroup is rarely infections. We present rare case conceptionense, senegalense complicating care patient with chronic moderate persistent asthma. CASE PRESENTATION: A 25-year-old female history asthma allergic rhinitis who presented clinic reticulonodular opacities left lung on chest x-ray, shortness breath, productive cough, hemoptysis. She had computed tomography (CT) revealing mucus plugging bilateral lower lobes bronchiectasis opacities. Acid-Fast Bacillus (AFB) cultures revealed senegalense. Treatment was started levofloxacin, doxycycline, azithromycin. Repeat CT 3 months after starting treatment improvement mucous plugging. Symptoms were improved minimal sputum production only occasional cough. AFB 3, 6, 9 unremarkable. DISCUSSION: RGMs described disease. Although incidence rare, pathogenic bacteria typically noted surgical wound infections, catheter-related disseminated cutaneous currently based off series individual experience. Cultures sterile following approximately 6 8 weeks. should be continued at least months. CONCLUSIONS: Further studies warranted delineate management, given rise these indolent their possible impact patients REFERENCE #1: Brown-Elliott B, Philley J. 2017. Rapidly mycobacteria. microbiolspec 5(1): doi:10.1128/microbiolspec.TNMI7-0027-2016 #2: Lipman M, Cleverley J, Fardon T, et al Current future management non-tuberculous mycobacterial disease (NTM-PD) UK BMJ Open Respiratory Research 2020;7:e000591. doi: 10.1136/bmjresp-2020-000591 #3: Ratnatunga CN, Lutzky VP, Kupz A, Doolan DL, Reid DW, Field Bell SC, Thomson RM Miles JJ (2020) Rise Non-Tuberculosis Mycobacterial Lung Disease. Front. Immunol. 11:303. 10.3389/fimmu.2020.00303 DISCLOSURES: No relevant relationships by Syed Zain Ayaz, source=Web Response Cynthia Tsai,